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AstraZeneca starts trial of COVID-19 antibody treatment

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first_imgTopics : AstraZeneca said on Tuesday it had begun testing an antibody-based treatment for the prevention and treatment of COVID-19, with the first participants dosed, adding to recent signs of progress on possible medical solutions to the disease.The British drugmaker, whose COVID-19 vaccine candidate is already among the most advanced, said the early-stage trial would evaluate if AZD7442, a combination of two monoclonal antibodies (mAbs), was safe and tolerable in up to 48 healthy participants between the ages of 18 and 55 years.If the UK-based trial has a positive readout, AstraZeneca said it would proceed with larger, mid-to-late-stage trials to test AZD7442 as both a preventative treatment for the disease and a medicine for patients who have it. mAbs mimic natural antibodies generated in the body to fight off infection and can be synthesized in the laboratory to treat diseases in patients and has been endorsed by top scientists. Current uses include treatment of some types of cancers.London-listed AstraZeneca in June received $23.7 million in funding from US government agencies to advance development of antibody-based treatments for the novel coronavirus.US based companies Regeneron and ELi Lilly are also testing mAbs-based treatments for COVID-19. last_img read more

Q&A with interim head coach Ed Orgeron

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first_imgDT: You’re making your debut as interim head coach, are you nervous at all or have any exciting jitters?Coach O: I guess come Thursday I will be a little fired up. I don’t know about nervous though; I will be fired up. DT: Have you planned how the game is going to go on the sidelines?Coach O: I think we are going to have to work it out as we go, but I really think it is going to help having Clay Helton on the sideline managing the offense, and me right there helping him talking about the offense. … I’m really going to be there to encourage, show enthusiasm and keep things going on. DT: Do you remember where to stand as a head coach?Coach O: Oh yeah, right in the middle of everybody. I will be fine. … I feel at home at the Coliseum. I’ve been there since 1998, and I know that it’s going to be a little bit different, but ever since I came to Los Angeles, I’ve felt at home. … I promise you this … I’m going to feel good being a head coach in cardinal and gold. DT: Do you have any kind of speech planned for before Thursday night’s game?Coach O: We’ve been preparing for this all week but come Thursday night when we get in the Coliseum, they’re going to be ready to go, but I’m sure I will have a couple of words to tell ’em. DT: What have you learned about game management and time management since the last time you had to do that as a head coach?Coach O: Make good, sound decisions, not emotional decisions. The last time that I was a head coach [at Ole Miss], I made a couple emotional decisions and it cost me. One time, I went for it on 4th and two when I shouldn’t have, and if I wasn’t as emotional, I would’ve made a better decision and I’ve learned from that.center_img DT: One of the things that Lane [Kiffin] had talked about for the past couple of years was whether he was focusing too much on the offense instead of being a head coach. Is that something you are going to be fighting or thinking about?Coach O: Not really … I’m going to do what I do best … coach toughness, style and energy throughout the whole game with the whole team. … I will be [with] the whole team as much as I can and we are going to give it everything we got. …  I plan on coaching the whole team and I’m going to be on the sideline. … Ross Cummins will go with [the defensive line] and him and Clancy [Pendergast] will make the proper adjustments. Though interim head coach Ed Orgeron has coached many games at the Los Angeles Memorial Coliseum, the spotlight has never truly been on him. That’ll change Thursday night.After practice on Tuesday during the last media session of the week, Daily Trojan staff writer Darian Nourian was there to see what “Coach O” is thinking ahead of his  head coaching debut at USC. Follow Darian on Twitter @dariannourian24last_img read more

Seniors add new tool to the lifesaving arsenal with Smart911

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first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisAlpena, Mich. — Carbon monoxide and smoke detectors, fire alarms, and escape plans are all important tools in keeping yourself as well as friends and family safe.On Thursday, seniors got a refresher on some important safety tips and information. Alpena City Fire Department community risk reduction officer Andy Marceau and 911 director Burt Francisco presented lifesaving tips, so that seniors can be ready, should an emergency arise. Both provided a few useful tools for seniors to protect themselves with. Two of those were carbon monoxide and smoke detectors that seniors can get help with installation by contacting the senior center.The other was a smart 911 app, where you can preload information like photographs, allergies, and other important notes about where you live and who lives there. This helps first responders have a better understanding when responding to a situation. They can look at the information, so they can anticipate an emergency instead of going in with little or no details.“When you call 911, it’s a very chaotic situation, and there is a lot of emotion, and they may not recall everything that they need to tell a dispatcher or emergency responder,” said Francisco. “During a time, a non-emergency time, they can go in and enter their information, which will expedite and make the 911 call more efficient to process with dispatcher.”Smart 911 is free and available in the app form or via website for all Michiganders. It can be extremely helpful in nonverbal communications as well. The technology is four years old and was introduced two years ago. It has seen a large increase in enrollment over the past year. You can fill in your information by visiting the website www.smart911.com.AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThis Tags: Alpena City Fire Department, Alpena County 911, Alpena Senior Citizens Center, Carbon Monoxide Detectors, Fire Alarms, First Responders, MICHIGAN, Seniors, Smart 911, Smoke DetectorsContinue ReadingPrevious Woman saves her dog before flames takeover carNext Laugh for a good cause in Oscoda this weekendlast_img read more

Dragons Wings cut off: Walters led Ireland to Euro with 2 Goals

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first_imgNational football team of B&H tonight was defeated by the team of Ireland at the Aviva Stadium in Dublin in the rematch of play-off for the European Championship that will be played next year in France. Dragons have lost with the score 2: 0.In the 23rd minute when Bjorn Kuipers awarded a penalty for Ireland after Zukanovic’s playing with hand in the penalty area. Walters checkmated Begovic for 1: 0. As soon as our team walked to the center, Dzeko hit the outer part of the net.Team of Mehmed Bazdarevic was unable to seriously threaten the goal of Ireland in the first half of hour. Medunjanin tried his shot in the 33rd minute but without any success.Dragons accepted style of game imposed by Ireland. They played long balls, and team of Ireland was removing the danger in front of their goal without much difficulty. The first half of the match ended with the score 1: 0.Dragons strongly attacked in the beginning of the second half. Visca engaged Lulic in the 55th minute. However, footballer of Lazio didn’t manage to carry out the ball in the crucial moment. After that, head coach of Ireland made a double substitution. He did not liked how his players started the second half.Miralem Pjanic’s shot was blocked in the 59th minute. Head coach Bazdarevic made a substitution and Milan Djuric entered the game in the 69th minutes instead of Medunjanin.In the 70th minute Walters defeated unsecure Begovic again for 2: 0. Then it became clear who is traveling to the European Championship in France.Team of Ireland controlled the game until the very end. Ireland qualified for the Euro and B&H team failed to reach the finals of a big competition in the extra qualifications.(Source: klix.ba)last_img read more

What time does the NASCAR race start today? Schedule, TV channel for Kansas

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first_imgThe previously postponed races at Dover and Michigan are now part of Saturday-Sunday doubleheaders at those respective tracks in August.Because New York requires people to quarantine for 14 days after traveling from one of the states impacted heavily by COVID-19 (including North Carolina), the Watkins Glen race on Aug. 16 was moved to the Daytona road course. According to The Athletic, NASCAR tried to get a quarantine waiver for its Watkins Glen races but was denied by Gov. Andrew Cuomo’s office.The Aug. 16 race will be the NASCAR Cup Series’ first on the road course at Daytona. The start time for Thursday’s NASCAR Cup Series race at Kansas Speedway is a later than originally scheduled now that it’s a night race in July rather than an afternoon race in late May. The rescheduled Kansas race not only has a new date and a new start time, but a new TV channel, too.Due to the same coronavirus pandemic-related issues that shut down live sports in March, NASCAR created a modified schedule of races for May, June and July that continues tonight at 7:30 p.m. ET at the 1.5-mile oval located in Kansas City, Kan. It is the second NASCAR Cup Series race scheduled to be shown on NBCSN this season. Scheduled to take the green flag shortly after 7:30 p.m. ET, Thursday night’s race at Kansas will feature 267 laps for a total of 400 miles.Below is all you need to know about the schedule for Thursday night’s NASCAR race at Kansas and beyond.MORE: Watch tonight’s NASCAR race live with fuboTV (7-day free trial)What time does the NASCAR race start today?Race: Super Start Batteries 400 presented by O’Reilly Auto Parts at Kansas SpeedwayDate: Thursday, July 23 Start time: 7:30 p.m. ET (Green flag at 7:48 p.m. ET)The green flag for Thursday night’s NASCAR Cup Series race at Kansas is scheduled to wave at 7:48 p.m. ET, assuming there are no rain delays as there have been so often since NASCAR returned to live racing in May.The Kansas race, rescheduled after it was postponed by the virus, was turned into a weeknight event rather than a Sunday afternoon race so NBCSN could benefit from such a time slot. The race is scheduled for 267 laps around the 1.5 mile oval in Kansas City, Kan.Kansas Speedway obviously has lights, so the later start time won’t have too much of an impact on NASCAR’s ability to get the race in late Thursday night in the event weather threatens a delay.What channel is NASCAR on today?TV channel: NBCSNLive stream: NBC Sports Go | fuboTV (7-day free trial)NBCSN is the TV channel for Thursday night’s race at Kansas even though it originally was scheduled to broadcast on FS1 before COVID-19 took its toll on the Cup Series schedule. Of the 20 NASCAR Cup Series races NBC will broadcast in 2020, 12 were scheduled to be shown on NBCSN with the other eight on NBC’s flagship cable network.As for Thursday night’s race on NBCSN, the network has a channel finder feature for viewers to find the TV channel options in their areas.As is the case for all the Cup Series races on NBC and NBCSN this season, Rick Allen will call the race with the assistance of analysts Dale Earnhardt Jr., Jeff Burton and Steve Letarte.NASCAR live stream for Kansas raceAnybody who has a cable or satellite subscription can stream Thursday night’s NASCAR race at Kansas live via NBCSports.com or the NBC Sports app. This should be the preferred route for a viewer who has such a subscription but isn’t able to get in front of his or her TV.For those who don’t have a cable or satellite subscription, there are five OTT TV streaming options that carry NBC and NBCSN — Sling, Hulu, YouTubeTV, fuboTV and AT&T Now. Of the five, Hulu, YouTubeTV and fuboTV offer free trial options.Below are links to each.SlingHulu (free trial)YouTubeTV (free trial)fuboTV (free trial)AT&T NowNASCAR schedule 2020NASCAR on July 8 released its latest revised Cup Series schedule through August of 2020. It remains committed to running 36 races, four of which were completed before the COVID-19 pandemic shut down the sports world. NASCAR hopes to keep its 10 playoff races in the fall intact and at their original tracks.Below is the schedule revision for the Cup Series regular season, starting with the races at Darlington the Cup Series ran in its return in May.DateTrackTV channelStart timeSun., May 17DarlingtonFOX3:30 p.m. ETWed., May 20DarlingtonFS17:30 p.m. ETSun., May 24CharlotteFOX6 p.m. ETWed., May 27CharlotteFS18 p.m. ETSun, May 31BristolFS13:30 p.m. ETSun, June 7AtlantaFOX3 p.m. ETWed, June 10MartinsvilleFS17 p.m. ETSun, June 14Homestead-MiamiFOX3:30 p.m. ETSun, June 21TalladegaFOX3 p.m. ETSat., June 27PoconoFOX3:30 p.m. ETSun., June 28PoconoFS14 p.m. ETSun., July 5IndianapolisNBC4 p.m. ETSun., July 12KentuckyFS12:30 p.m. ETWed., July 15Bristol (All-Star Race)FS18:30 p.m. ETSun., July 19TexasNBCSN3 p.m. ETThurs., July 23KansasNBCSN7:30 p.m. ETSun., Aug. 2New HampshireNBCSN3 p.m. ETSat., Aug. 8MichiganNBCSN4 p.m. ETSun., Aug. 9MichiganNBCSN4:30 p.m. ETSun., Aug. 16Daytona (road course)NBC3 p.m. ETSat., Aug. 22DoverNBCSN4 p.m. ETSun. Aug. 23DoverNBCSN4 p.m. ETSat., Aug. 29DaytonaNBC7:30 p.m. ETThe Darlington race on May 17 ran instead of the the Chicagoland race that was originally scheduled for June 21. The Darlington race on May 20 ran instead of the postponed Richmond race that was originally scheduled for April 19. The Charlotte race on May 27 ran instead of the Sonoma race that was originally scheduled for June 14.The Pocono doubleheader remained as previously scheduled for the final weekend of June, with the Cup Series racing on back-to-back days. Those races were presented on Fox (and FS1) rather than on NBC. Fox closed its coverage this season with the All-Star Race at Bristol on July 15.last_img read more